The Middle School Program at Catholic Central School is modeled on the Jesuit-based Nativity Network, which opened its first school in 1971 on the Lower East Side of New York City for students who could not afford private school education. The students are offered an extended day, week and year in order to separate them from the violence of the street culture. The single gender, small class setting allows for confidence building, healthy self-awareness, and higher academic achievement. The overall goal is to give young women and young men the opportunity to become successful members of the community.

Today, the Nativity schools have joined with the Lasallian San Miquel schools in a network (www.nativitymiguelschools.org) of more than 50 private, independent Catholic schools nationwide. An impressive 88 percent of these students graduate from high school and 92 percent of these go on to college. An essential component of the Nativity school model is the support it offers to the graduates as they continue their education through high school and into post-secondary education. The Graduate Assistance Program provides academic resources, financial aid, and personal guidance through high school and into college.

Since September 2004, the Saint Monica Scholars and the Saint Augustine Scholars, called after the African Saints, have been offering intervention in the lives of inner city girls and boys in 6th, 7th, and 8th grades. The program's success is already evident in Buffalo with graduates of Catholic Central now attending the top private and public high schools in Western New York. Financial assistance is provided through the POLARIS Fund: the Project for Learning, Achievement and Responsibility for Inner-City Students, Inc.